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Glutathione redox control of asthma: From molecular mechanisms to therapeutic opportunities

In contrast to the liver, the lung is composed of many different cell types and expression of GSTs in different human lung cell types is heterogenous

The split dosing maintains more consistent tissue concentrations given peptide half-lives

and Kharchenko, P.V

To understand the dynamics of this interplay in T1DM, one must go back to the relation between portal insulin and GHR expression on hepatocytes, which was so cleverly addressed by Leung et al